Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate
نویسندگان
چکیده
منابع مشابه
Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate
We have examined the tolerance of the spindle assembly checkpoint (SAC), as measured by the appearance of tetraploid cells in the presence of a microtubule inhibitor, in a series of primary cell strains derived from species with diverse lifespan and body size. We find that the integrity of the SAC varies among these species. There is a robust correlation between the integrity of the SAC and bod...
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Italian in 1954, so Imanishi turned to the exploration of the unexplored wide range of Karakorum Himalayas, traversing the three major glaciers in 1955. Then, in 1958, Imanishi and Itani went to Africa for the first time. In the same year, Nishibori led the all-Japanese team which succeeded in the first over-wintering stay in Antarctica. Kuwabara led the Himalayan expedition of AACK to the firs...
متن کاملThe Spindle Assembly Checkpoint
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint ...
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The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are properly attached to the mitotic spindle. Inhibition of Cdc20 is mediated by a conserved network of interacting proteins. The individual functions ...
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The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain controversial. We generated a HeLa cell line in which two components of the kinetochore, centrome...
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ژورنال
عنوان ژورنال: Aging
سال: 2011
ISSN: 1945-4589
DOI: 10.18632/aging.100416